Protease Activated Receptor (PAR)

Protease Activated Receptor (PAR) Related Products (23):

By Effects:	Inhibitors (2) Agonists (8) Antagonists (7) Activators (2)

Cat. No.	Product Name	Effect	Purity

HY-P4803

PAR-2 (1-6) (human)	Agonist	99.49%
PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist.

HY-P2519A

Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA	Agonist	99.86%
Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide.

HY-P4987

TRAP-7	Activator	99.66%
TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated PKC. TRAP-7 can be used in cardiovascular disease research.

HY-P5875A

P4pal10 TFA	Antagonist	98.25%
P4pal10 TFA is the TFA salt form of P4pal10 (HY-P5875). P4pal10 TFA is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 TFA inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 TFA reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 TFA ameliorates the injury in rats myocardial ischemia/reperfusion (I/R) models.

HY-14351

AC-264613	Agonist	98.3%
AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC₅₀ of 7.5.

HY-114164C

Thrombin, Pig blood	Activator
Thrombin, Pig blood is a key enzyme in the coagulation cascade, responsible for converting fibrinogen into fibrin. Thrombin, Pig blood activates platelet activation, endothelial cell function, and inflammatory responses by binding to PAR-1 and PAR-4, which triggers G protein-coupled signaling pathways. Thrombin, Pig blood holds promise for research in coagulation and inflammation fields.

HY-P2380

PAR3 (1-6) (human)
PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.

HY-P5360

TFLLRN-NH2	Agonist	99.34%
TFLLRN-NH2 is a biological active peptide. (PAR-1 Agonist)

HY-W006069

H-Phe(3,5-DiF)-OH
H-Phe(3,5-DiF)-OH is a difluorophenylalanines in the L-configuration [L-(F2)Phe]. H-Phe(3,5-DiF)-OH can be incorporated into the thrombin receptor-tethered ligand peptide SFLLRNP to identify the phenyl hydrogens of the Phe-2 residue involved in the CH/π receptor interaction.

HY-P1536

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).

HY-10119S

Vorapaxar-d₅	Antagonist
Vorapaxar-d₅ is deuterated labeled Vorapaxar (HY-10119). Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.

HY-P2519

Protease-Activated Receptor-3 (PAR-3) (1-6), human	Agonist
Protease-Activated Receptor-3 (PAR-3) (1-6), human is a proteinase-activated receptor (PAR-3) agonist peptide.

HY-124663

CBK289001	Inhibitor
CBK289001 is a tartrate-resistant acid phosphatase (TRAP/ACP5) inhibitor. CBK289001 inhibits TRAP 5b^MV, TRAP 5b^OX and TRAP 5a^OX with IC₅₀s of 125 µM, 4.21 µM and 14.2 µM, respectively.

HY-P5372

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2	Agonist
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biological active peptide. (Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.)

HY-162762

PAR-2 antagonist 1	Antagonist
PAR-2 antagonist 1 (Compound 9a) is a protease-activated receptor 2 (PAR2) antagonist with an IC₅₀ value of 0.9 μM. PAR-2 antagonist 1 can effectively inhibit the proliferation and migration of breast cancer cells.

HY-108554

Q94 hydrochloride	Antagonist
Q94 hydrochloride, a selective PAR₁ antagonist (IC₅₀=916 nM), can selectively block PAR₁/Gαq interaction and signalling. Q94 hydrochloride blocks PAR₁-mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation.

HY-143313

Protease-Activated Receptor-1 antagonist 1	Antagonist
Protease-Activated Receptor-1 antagonist 1 (Compound 13) is a protease-activated receptor-1 (PAR-1) antagonist with the IC₅₀ of 3 nM by FLIPR technology. Protease-Activated Receptor-1 antagonist 1 can be used for the research of thrombotic cardiovascular, myocardial infarction, and peripheral arterial disease.

HY-P5357

SFNGGP-NH2
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)

HY-P5358

YFLLRNP	Agonist
YFLLRNP is a biological active peptide. (a partial agonist of PAR-1. YFLLRNP selectively active G12/13 signaling pathway without activating Gq or Gi pathways at low concentrations. YFLLRNP (60 μM))

HY-P1313

PAR 4 (1-6) (human)	Agonist
PAR 4 (1-6) human, a hexapeptide, is a fragment of protease-activated receptor 4 (PAR₄). PAR 4 (1-6) TFA acts as a PAR₄-specific agonist.

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