Protease Activated Receptor (PAR)

Protease Activated Receptor (PAR) Related Products (35):

By Effects:	Inhibitors (4) Controls (3) Agonists (8) Antagonists (11) Activators (4)

Cat. No.	Product Name	Effect	Purity

HY-P4803

PAR-2 (1-6) (human)	Agonist	99.53%
PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist.

HY-P2519A

Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA	Agonist	99.86%
Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide.

HY-14351

AC-264613	Agonist	98.3%
AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC₅₀ of 7.5.

HY-P4987

TRAP-7	Activator	99.66%
TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated PKC. TRAP-7 can be used in cardiovascular disease research.

HY-P5875A

P4pal10 TFA	Antagonist	98.25%
P4pal10 TFA is the TFA salt form of P4pal10 (HY-P5875). P4pal10 TFA is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 TFA inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 TFA reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 TFA ameliorates the injury in rats myocardial ischemia/reperfusion (I/R) models.

HY-129047D

Trypsin, Human Pancreas	Activator
Trypsin, Human Pancreas is a serine protease that hydrolyses proteins into peptides and amino acids, and is an improtant enzyme for digestive system. Trypsin, Human Pancreas activates kallikrein and regulates the blood pressure. Trypsin, Human Pancreas is an activator for PAR, thereby regulating cellular inflammatory and immune responses.

HY-159895

PAR4 antagonist 7	Antagonist
PAR4 antagonist 7 (Compound 20f) is selective PAR4 antagonist (IC₅₀: 1.72 nM). PAR4 antagonist 7 inhibits PAR4 agonist-induced platelet aggregation. PAR4 antagonist 7 has good metabolic stability. PAR4 antagonist 7 does not show a bleeding tendency in mice.

HY-10119AR

Vorapaxar (sulfate) (Standard)	Antagonist
Vorapaxar (sulfate) (Standard) is the analytical standard of Vorapaxar (sulfate). This product is intended for research and analytical applications. Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.

HY-P4004

PAR-4 (1-6) amide (human)		98.82%
PAR-4 (1-6) amide human is an N-terminal fragment of protease-activated receptor 4 (PAR4). PAR-4 (1-6) amide human induce platelet aggregation.

HY-P5360

TFLLRN-NH2	Agonist	99.34%
TFLLRN-NH2 is a biological active peptide. (PAR-1 Agonist)

HY-114164C

Thrombin, Pig blood	Activator
Thrombin, Pig blood is a key enzyme in the coagulation cascade, responsible for converting fibrinogen into fibrin. Thrombin, Pig blood activates platelet activation, endothelial cell function, and inflammatory responses by binding to PAR-1 and PAR-4, which triggers G protein-coupled signaling pathways. Thrombin, Pig blood holds promise for research in coagulation and inflammation fields.

HY-124663

CBK289001	Inhibitor
CBK289001 is a tartrate-resistant acid phosphatase (TRAP/ACP5) inhibitor. CBK289001 inhibits TRAP 5b^MV, TRAP 5b^OX and TRAP 5a^OX with IC₅₀s of 125 µM, 4.21 µM and 14.2 µM, respectively.

HY-P1312A

LRGILS-NH2 TFA	Control	98.90%
LRGILS-NH2 TFA is a reverse-sequence protease-activated receptor-2 (PAR-2)-inactive, negative control, and SLIGRL-NH2 is a PAR-2-activating peptide.

HY-105999B

APC 366 TFA	Inhibitor	≥99.0%
APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases.

HY-W006069

H-Phe(3,5-DiF)-OH
H-Phe(3,5-DiF)-OH is a difluorophenylalanines in the L-configuration [L-(F2)Phe]. H-Phe(3,5-DiF)-OH can be incorporated into the thrombin receptor-tethered ligand peptide SFLLRNP to identify the phenyl hydrogens of the Phe-2 residue involved in the CH/π receptor interaction.

HY-P1536

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).

HY-10119S

Vorapaxar-d₅	Antagonist
Vorapaxar-d₅ is deuterated labeled Vorapaxar (HY-10119). Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.

HY-P2519

Protease-Activated Receptor-3 (PAR-3) (1-6), human	Agonist
Protease-Activated Receptor-3 (PAR-3) (1-6), human is a proteinase-activated receptor (PAR-3) agonist peptide.

HY-P1312

LRGILS-NH2	Control
LRGILS-NH2 is a reverse-sequence protease-activated receptor-2 (PAR-2)-inactive, negative control, and SLIGRL-NH2 is a PAR-2-activating peptide.

HY-P1311A

RLLFT-NH2 TFA	Control
RLLFT-NH2 TFA is a reversed amino acid sequence negative control peptide for TFLLR-NH2 (HY-P0226).

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